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Bio-stimulators are a breakthrough in aesthetic medicine and an excellent solution for those who have tired, dry skin with aging signs, such as sunken cheeks, wrinkles or loss of defined facial oval. Bio-stimulators include preparations based on peptides, calcium hydroxyapatite, collagen, amino acids or L-polylactic acid and, of course, hyaluronic acid.
Each of them has a slightly different composition and produces different effects. However, they all have one thing in common: they are state-of-the-art solutions and have high effectiveness. Thanks to them, you can lift tissues without the produced by fillers or moisturise the skin better than mesotherapy.
Stimulators encourage the skin to self-renew by stimulating fibroblasts and production of collagen and elastin.
Bio-stimulators are also a great alternative to classic mesotherapy for people who are afraid of needles – some preparations require only 4-5 insertions to nourish the whole face!
During the consultation, a physician will help you choose the most suitable type of Bio-stimulators .


Aging means diminished ability of cells to respond to environmental stress. This results in a natural and irreversible accumulation of intracellular damage that overwhelms the body’s ability to repair itself.
This is a progressive process that begins around the age of 25. The process of turning the first wrinkles to more visible folds, and volume loss to skin sagging, usually takes several decades! Facial skin aging cannot be compared to the aging of the rest of the body because facial skin is subject to facial expressions and the force of gravity. Constant movements of the skin as well as sun exposure, smoking and poor nutrition are responsible for skin aging. Genetic factors also play an important role. We know more and more about the factors that accelerate aging, and we gain more and more knowledge about how to slow down this natural physiological phenomenon and even improve some aspects related to it.
There are two types of skin aging: intrinsic aging, or the consequence of passage of time, which affects every organism and depends on genetic and physiological factors, sometimes also on disease factors, and extrinsic aging, associated with conditions and lifestyle, primarily sun exposure, but also tobacco intoxication, stress or pollution. At the intersection of both processes, there is oxidative stress, one of the main causes of skin aging. It is caused primarily by free radicals, which biologically damage the structures of our cells. The body itself also produces free radicals, but our cells have an appropriate defence system against their negative effects. As we age, a mismatch develops between these irritations and our ability to defend ourselves.
Fortunately, modern aesthetic medicine rushes to help. Using a wide range of less and more invasive procedures, we are able to significantly slow down or even partially reverse the effects of aging.


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During the consultation, we discuss the expected effect and chose the best method for the Patient. Before the treatment an anaesthetic ointment is applied, which significantly reduces pain sensations – the injections feel similar to mosquito bites. During the procedure, a selected preparation is administered in a form adjusted to the technique.


Redness and bubbles, which usually appear at the site of injections after administration of tissue stimulator, disappear within 1-2 days. In addition, swelling or discomfort may occur. It must be remembered that some stimulators are designed to cause controlled inflammation. You will be informed about the expected healing process by a physician performing the procedure.


The procedure does not require much preparation.

Do not consume alcohol, caffeine or drugs 24 hours before the procedure.

One week before the procedure, do not take common painkillers, as they thin the blood and may cause more bruising after insertions. Garlic and onion have a similar effect.

If you take NSAIDs, talk to your GP and ask if you can discontinue them two weeks before your procedure. If your GP refuses, don’t discontinue your medication on your own! The procedure can still be performed, but you must expect more bruising.

Two weeks before the procedure, you can start taking vitamin C, which will strengthen capillary walls and thus reduce formation of bruises.


The effects of bio-stimulators appear at different times, depending on the preparation used. The effects are usually not visible right away, but they gradually gain strength and last from about 6 months to 2 years.

Bio-stimulators tighten and moisturise the skin, eliminate fine wrinkles. The oval of the face is elevated, cheekbones become more prominent, dark circles and puffiness under the eyes are reduced. In addition, deep folds become shallower and the whole skin looks radiant. With certain products, visibility of any acne scars or stretch marks are reduced when applied to the body.

As a result, the aging process is effectively slowed down, and the face gains a “fresh” look without the obvious interference of aesthetic medicine.


There are not many contraindications to tissue stimulator treatment but they must be taken into consideration. Below you will find the most important of them.

Asymptomatic carrier of hepatitis B or hepatitis C.

Viral hepatitis often affects autoimmune reactions. It mainly depends on the stage of the disease as well as its activity. Only your attending physician may decide whether you are eligible for a aesthetic medicine procedure. Ask them for a written consent for the procedure. Only then, we can perform the procedure.


In case of advanced diabetes wound healing is impaired. However, when treated and controlled, diabetes is not a problem. If you have diabetes, please ask your attending physician for a written consent for the aesthetic medicine procedure and present it to us on the day of the procedure.

Active cancer.

Cancer that occurred less than 5 years prior to the procedure.

Chemo- and radiotherapy

Autoimmune diseases apart from thyroid disease, acquired vitiligo, and alopecia areata. For example, these diseases include psoriasis, rheumatoid arthritis, lupus, myasthenia gravis, multiple sclerosis, amyotrophic lateral sclerosis, sarcoidosis, Crohn’s disease, ulcerative colitis.

Treatment with Izotec or its substitutes less than 6 months prior the procedure date.

Steroids, except asthma medications and inhaled steroids, taken less than one month prior to the scheduled procedure.

Fungal medications or antibiotics taken less than one week prior to the procedure.

Tendency to keloids.



Pregnancy and breastfeeding. We do not perform procedures in pregnant ladies or nursing mothers, even with the physician’s consent. When it comes to children, one can’t be too careful!

Asymptomatic HIV infection or active AIDS.

Skin diseases in the planned treatment site.

Fever, viral or bacterial infection on the day of the procedure.



Our clinic was established in 2005, thanks to which we have gained vast experience. We have performed over 30,000 procedures. We are also one of the leading training facilities for physicians and cosmetologists in Poland.


At Princesse®, we use only the highest quality preparations obtained directly from manufacturers. Avoiding wholesalers, we fully reduce the risk of purchasing inauthentic or substandard products.


We have all medical devices that are needed in case of sudden complications and we employ physicians with experience not only in treating aesthetic medicine complications but also in emergency procedures.


Princesse® is a modern aesthetic medicine clinic and training centre. It was established in 2005. Thanks to extensive experience and over 30,000 procedures performed to date, we have been able to select only the best procedures and equipment.
Princesse® employs highly specialised medical and cosmetology staff, who continue to improve their skills by participating in seminars and conferences devoted to the fields they practice, both in Poland and worldwide.
At Princesse®, we focus on naturalness and perfection as well as spectacular effects presented by models and celebrities. We believe that aesthetic medicine procedures are meant not to be a disguise, but to emphasise and highlight the strengths that each of us has.




Opening hours:

Mon-Fri: 10.00 AM-6.00 PM

Sat-Sun: closed


Our clinic

is disabled-friendly.

Address in Cracow

Cracow, Old Town

ul. Józefa Dietla 50/15

31-039 Cracow


Trams no. 18, 22, 52.


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